Clinical Studies

Clinical Studies on the Effectiveness of Scalp Cooling

Scalp cooling is a proven method for preventing chemotherapy-induced hair loss. Below is a selection of clinical studies published in reputable scientific journals that demonstrate its effectiveness and safety.

1. Rugo et al. (JAMA, 2017)
Title: Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer
Summary: Randomized study showing a significant reduction in alopecia in patients using a scalp cooling cap during chemotherapy.
🔗 Read on PubMed

2. Clinical Trial NCT04678544 (2024)
Title: Scalp Cooling Reduces Incidence of Persistent Alopecia After Chemotherapy
Summary: Study demonstrating that scalp cooling reduces persistent hair loss after chemotherapy.
🔗 Read on PubMed

3. van den Hurk et al. (2023)
Title: Scalp Cooling for Chemotherapy-Induced Alopecia: Real-World Data from 7,424 Patients
Summary: 53% of patients reported minimal hair loss (WHO score 0/1). Effectiveness depended on chemotherapy type and dosage.
🔗 Read on PubMed

4. Brunner et al. (2022)
Title: Efficacy of Scalp Cooling for the Prevention of Chemotherapy-Induced Alopecia
Summary: Significant reduction in hair loss, although the effect on post-treatment regrowth was not statistically significant.
🔗 Read on PubMed

5. Bajpai et al. (2019)
Title: Randomized Trial of Scalp Cooling for the Prevention of Chemotherapy-Induced Alopecia in Breast Cancer Patients
Summary: Patients using a scalp cooling cap experienced significantly reduced alopecia and better psychological well-being.
🔗 Read on PubMed

6. Vasconcelos et al. (2018)
Title: Efficacy of Scalp Cooling in Breast Cancer Patients Undergoing Chemotherapy
Summary: Positive results in preventing alopecia with minimal side effects.
🔗 Read on PubMed

7. Nangia et al. (2017)
Title: Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients
Summary: Significant reduction in hair loss in a multicenter trial.
🔗 Read the VIDAL article

8. Clinical Trial NCT01986140
Title: A Study of the Orbis Paxman Hair Loss Prevention System in Breast Cancer Patients
Summary: Randomized study measuring hair retention after four cycles of chemotherapy.
🔗 Study protocol – PDF ClinicalTrials.gov

9. Scientific Review (Nature, 2019)
Title: Scalp Cooling Prevents Chemotherapy-Induced Alopecia in Early Breast Cancer
Summary: Study showing significant hair preservation as early as the 4th chemotherapy cycle.
🔗 Read on Nature

10. ScienceDirect – Scalp Cooling Review (2020)
Title: Effectiveness of Scalp Cooling Based on Chemotherapy Type
Summary: Cooling is particularly effective for taxane-based chemotherapies.
🔗 Read on ScienceDirect

In Summary

Scalp cooling is clinically validated as an effective method to prevent chemotherapy-induced hair loss.
Its effectiveness depends on the type of chemotherapy, the protocol used, and the patient’s individual profile.
According to current studies, it is considered safe with no documented increase in the risk of scalp or other metastases.